Patrícia Carneiro
Name: Patrícia Carneiro
Academic Degree: PhD

Patrícia Carneiro
Patrícia Carneiro
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Patrícia Carneiro (PC) holds a PhD in Biomedical Sciences from Instituto de Ciências Biomédicas Abel Salazar, University of Porto, and is the Scientific Manager at Porto. Comprehensive Cancer Centre. Previously she completed her Master in Biology and Biological Sciences in 2002 at Washington University in Saint Louis and her Bachelor in BSc. Human Genetics in 1998 at University of Leeds, School of Biomedical Sciences. Since 2012, PC has been devoted to understand the mechanisms of epithelial cell invasion at IPATIMUP/i3S. In this context, she has identified key molecules associated to cancer cell invasion and E-cadherin dysfunction. PC has 24 publications in international peer-reviewed journals (7 as first-author) with an h-index 14. 

Germline mutations in tumor suppressor genes (TSGs) predispose to hereditary cancer. Despite that mutations are constitutionally present, cancer only occurs in specific tissues. This is the case for CDH1 germline mutation in hereditary diffuse gastric cancer syndrome (HDGC), where carriage of the abnormal CDH1 gene confers more than 80% lifetime risk to specifically develop gastric cancer.
What is not yet known in HDGC is the tissue specific molecular determinants behind the predominant increased risk for stomach cancer although E-cadherin is expressed in all epithelial tissues. We hypothesise that only gastric cells are able to overcome apoptosis mediated by E-cadherin biallelic inactivation and thus become more prone to acquire de novo alterations and at higher risk for transformation.
Our project aims to identify the gastric-specific gene expression profile that allows stomach epithelial cells to resist apoptosis induced by E-cadherin loss.

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