Joana Paredes
Name: Joana Paredes
Academic Degree: PhD

Joana Paredes
Joana Paredes
Member of
Coordinator of In vivo CAM Assays
Researcher of Cancer Metastasis

Short CV

Joana Paredes (JParedes) is the group leader of the Cancer Metastasis group at i3S and Affiliated Professor at the Faculty of Medicine of the University of Porto. Currently, she is also the President of the Portuguese Association for Cancer Research (ASPIC).

JParedes graduated in Biology at Coimbra University in 1999 and completed her PhD at the Faculty of Medicine of Porto University in 2004. For 2 years, she worked in the Cancer Research Laboratory of Gent University (Belgium), a reference lab in cell-cell adhesion and cancer. 

Throughout JParedes’ scientific research career, she has been always committed to understand how cell-cell adhesion signaling regulates collective cell invasion, metabolic behavior and stem cell properties of cancer cells, supporting the use of adhesion molecules as prognostic and predictive biomarkers in cancer. As Principal Investigator, her research focus is to challenge the dogma that cell-cell adhesion needs to be lost for cancer cells to invade and metastasize. Using breast cancer as a model, she demonstrated that cell-cell adhesion mediated by P-cadherin provides invasive and stem-like properties to cancer cells. Recently, she showed that P-cadherin expression can be induced by hypoxia, which then activates the pentose phosphate pathway and decreases oxidative stress in matrix-detached breast cancer cells. These results led her to believe that cell-cell adhesion award plasticity and a survival advantage to cancer cells while in circulation, being determinant for an increased metastatic behavior.

JParedes has published 81 articles in international peer-reviewed journals and 4 book chapters. These manuscripts have gathered more than 3200 citations by peers, endowing her an h-index of 36. She already coordinated 14 and participated in 11 research projects and already acted as a reviewer of post-doc and PhD fellowships, as well as of scientific projects, for national and international agencies. As a mentor, JParedes has already supervised or co-supervised 8 PhD students and 17 MSc students.


Supervisor of
Ana Ribeiro, Assistant Researcher
Assistant Researcher
Bruno Freitas, PhD Student
PhD student
Catarina Lourenço, PhD Student
PhD student
Inês Conde, PhD Student
PhD student
Kateryna Lebedenko, Research Trainee
Research Trainee
Nuno Mendes, PhD Student
PhD student

PI (running)

PI (closed)
First Author
1. Paredes J, Figueiredo J, Albergaria A, Oliveira P, Carvalho J, Ribeiro AS, Caldeira J, Costa AM, Simões-Correia J, Oliveira MJ, Pinheiro H, Pinho SS, Mateus R, Reis CA, Leite M, Fernandes MS, Schmitt F, Carneiro F, Figueiredo C, Oliveira C, Seruca R
Epithelial E- and P-cadherins: Role and clinical significance in cancer. Biochimica et Biophysica acta-Reviews on Cancer 1826: 297-311, 2012. [Review] 
2. Paredes J, Correia AL, Ribeiro AS, Milanezi F, Cameselle-Teijeiro J, Schmitt FC
3. Paredes J, Correia AL, Ribeiro AS, Albergaria A, Milanezi F, Schmitt FC
P-cadherin expression in breast cancer: a review. Breast cancer research : BCR 9: 214, 2007. [Review] 
 doi: 10.1186/bcr1774 PMID: 18001487.
4. Paredes J, Lopes N, Milanezi F, Schmitt FC
P-cadherin and cytokeratin 5: useful adjunct markers to distinguish basal-like ductal carcinomas in situ. Virchows Archiv : an international journal of pathology 450: 73-80, 2007. [Article] 
5. Paredes J, Correia AL, Ribeiro AS, Schmitt F
Expression of p120-catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines. Cellular oncology : the official journal of the International Society for Cellular Oncology 29: 467-76, 2007. [Article] 
 PMID: 18032823.
6. Paredes J, Albergaria A, Oliveira JT, Jerónimo C, Milanezi F, Schmitt FC
P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Clinical cancer research : an official journal of the American Association for Cancer Research 11: 5869-77, 2005. [Article] 
7. Paredes J, Stove C, Stove V, Milanezi F, Van Marck V, Derycke L, Mareel M, Bracke M, Schmitt F
8. Paredes J, Milanezi F, Viegas L, Amendoeira I, Schmitt F
P-cadherin expression is associated with high-grade ductal carcinoma in situ of the breast. Virchows Archiv : an international journal of pathology 440: 16-21, 2002. [Article] 
 PMID: 11942571.
9. Paredes J, Milanezi F, Reis-Filho JS, Leitão D, Athanazio D, Schmitt F
Aberrant P-cadherin expression: is it associated with estrogen-independent growth in breast cancer? Pathology, research and practice 198: 795-801, 2002. [Article] 
 PMID: 12608656.
Senior Author
2. Noronha C, Ribeiro AS, Taipa R, Castro DS, Reis J, Faria C, Paredes J
Cadherin Expression and EMT: A Focus on Gliomas. Biomedicines 9: ., 2021. [Review] 
The Chick Chorioallantoic Membrane Model: A New In Vivo Tool to Evaluate Breast Cancer Stem Cell Activity. International journal of molecular sciences 22: ., 2020. [Article] 
4. Sousa B, Pereira J, Marques R, Grilo LF, Pereira SP, Sardão VA, Schmitt F, Oliveira PJ, Paredes J
5. Dionísio MR, Vieira AF, Carvalho R, Conde I, Oliveira M, Gomes M, Pinto MT, Pereira P, Pimentel J, Souza C, Marques MMC, Duval da Silva V, Barroso A, Preto D, Cameselle-Teijeiro JF, Schmitt F, Ribeiro AS, Paredes J
The Crosstalk Between Cell Adhesion and Cancer Metabolism. International journal of molecular sciences 20: ., 2019. [Review] 
Heterogeneity and Plasticity of Breast Cancer Stem Cells. Advances in experimental medicine and biology 1139: 83-103, 2019. [Article; Book Chapter] 
8. Silva MR, Marques R, Sousa B, Sardao VA, Oliveira PJ, Paredes J
P-cadherin effect in mitochondrial dynamics and biogenesis of breast cancer cells European Journal of Clinical Investigation 49: 185-186, 2019. [Meeting Abstract] 
9. Ribeiro AS, Nobre AR, Mendes N, Almeida J, Vieira AF, Sousa B, Carvalho FA, Monteiro J, Polónia A, Fonseca M, Sanches JM, Santos NC, Seruca R, Paredes J
SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells. Cell communication and signaling : CCS 16: 75, 2018. [Article] 
10. Polónia A, Pinto R, Cameselle-Teijeiro JF, Schmitt FC, Paredes J
11. Vieira AF, Dionísio MR, Gomes M, Cameselle-Teijeiro JF, Lacerda M, Amendoeira I, Schmitt F, Paredes J
P-cadherin: a useful biomarker for axillary-based breast cancer decisions in the clinical practice. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 30: 698-709, 2017. [Article] 
12. Ribeiro AS, Carvalho FA, Figueiredo J, Carvalho R, Mestre T, Monteiro J, Guedes AF, Fonseca M, Sanches J, Seruca R, Santos NC, Paredes J
 doi: 10.1039/c6nr04465d PMID: 27847941.
13. Vieira AF, Paredes J
P-cadherin and the journey to cancer metastasis. Molecular cancer 14: 178, 2015. [Review] 
15. Vieira AF, Ribeiro AS, Dionísio MR, Sousa B, Nobre AR, Albergaria A, Santiago-Gómez A, Mendes N, Gerhard R, Schmitt F, Clarke RB, Paredes J
 PMID: 24553076.
16. Sousa B, Ribeiro AS, Nobre AR, Lopes N, Martins D, Pinheiro C, Vieira AF, Albergaria A, Gerhard R, Schmitt F, Baltazar F, Paredes J
17. Ribeiro AS, Sousa B, Carreto L, Mendes N, Nobre AR, Ricardo S, Albergaria A, Cameselle-Teijeiro JF, Gerhard R, Söderberg O, Seruca R, Santos MA, Schmitt F, Paredes J
 doi: 10.1002/path.4143 PMID: 23180380.
18. Vieira AF, Ricardo S, Ablett MP, Dionísio MR, Mendes N, Albergaria A, Farnie G, Gerhard R, Cameselle-Teijeiro JF, Seruca R, Schmitt F, Clarke RB, Paredes J
 doi: 10.1002/stem.1075 PMID: 22389315.
19. Schmitt F, Ricardo S, Vieira AF, Dionísio MR, Paredes J
Cancer stem cell markers in breast neoplasias: their relevance and distribution in distinct molecular subtypes. Virchows Archiv : an international journal of pathology 460: 545-53, 2012. [Review] 
20. Ricardo S, Gerhard R, Cameselle-Teijeiro JF, Schmitt F, Paredes J
Claudin expression in breast cancer: High or low, what to expect? Histology and histopathology 27: 1283-95, 2012. [Article] 
 PMID: 22936447.
21. Ricardo S, Vieira AF, Gerhard R, Leitão D, Pinto R, Cameselle-Teijeiro JF, Milanezi F, Schmitt F, Paredes J
22. Ribeiro AS, Albergaria A, Sousa B, Correia AL, Bracke M, Seruca R, Schmitt FC, Paredes J
Send Email