Ipatimup

Name: Patrícia Carneiro

E-mail: pcarneiro@ipatimup.pt

Patrícia Carneiro

Member of

Junior Researcher of Epithelial Interactions in Cancer

Short CV

EDUCATION
2012 ICBAS Portugal
PhD Biomedical Sciences
2001 Washington University USA
M.Sc. Developmental Biology
1998 The University of Leeds U.K.
B.Sc. (Hons) Human Genetics
Thesis Grade:1
Final Grade: 2.1

CURRENT SITUATION
02/2012- Ipatimup, Portugal Post-Doc at Cancer Genetics

PROFESSIONAL EXPERIENCE
11/2001 – 12/2011 IBMC, PortugalResearcher in the Research Group “Genetics of Mitochondria”
01/2001 – 06/2001 Washington University, USA Teaching Assistant for “Fundamentals of Biology 296”
08/1999 – 09/2001 Washington University, USA Graduate Student in the Program “Developmental Biology”
01/1999 – 07/1999 Washington University, USA Laboratory Assistant
06/1998 – 12/1998 University of Leeds, UK Laboratory Assistant / Teaching Assistant for ""Developmental Biology""

Highlights

Germline mutations in tumor suppressor genes (TSGs) predispose to hereditary cancer. Despite that mutations are constitutionally present, cancer only occurs in specific tissues. This is the case for CDH1 germline mutation in hereditary diffuse gastric cancer syndrome (HDGC), where carriage of the abnormal CDH1 gene confers more than 80% lifetime risk to specifically develop gastric cancer.
What is not yet known in HDGC is the tissue specific molecular determinants behind the predominant increased risk for stomach cancer although E-cadherin is expressed in all epithelial tissues. We hypothesise that only gastric cells are able to overcome apoptosis mediated by E-cadherin biallelic inactivation and thus become more prone to acquire de novo alterations and at higher risk for transformation.
Our project aims to identify the gastric-specific gene expression profile that allows stomach epithelial cells to resist apoptosis induced by E-cadherin loss.

Supervisor of

Ana Moreira, PhD Student

First Author

1. Carneiro P, Figueiredo J, Bordeira-Carriço R, Fernandes MS, Carvalho J, Oliveira C, Seruca R

Therapeutic targets associated to E-cadherin dysfunction in gastric cancer. Expert opinion on therapeutic targets 17: 1187-201, 2013. [Review]

doi: 10.1517/14728222.2013.827174 PMID: 23957294.

4.9

2. Carneiro P, Fernandes MS, Figueiredo J, Caldeira J, Carvalho J, Pinheiro H, Leite M, Melo S, Oliveira P, Simões-Correia J, Oliveira MJ, Carneiro F, Figueiredo C, Paredes J, Oliveira C, Seruca R

E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions. FEBS letters 586: 2981-9, 2012. [Review]

doi: 10.1016/j.febslet.2012.07.045 PMID: 22841718.

3.6