1. Figueiredo J, Melo S, Gamet K, Godwin T, Seixas S, Sanches JM, Guilford P, Seruca R

E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer. Molecular cancer 17: 112, 2018.  [Article] 

 doi: 10.1186/s12943-018-0859-0 PMID: 30068367.

 

2. Corso G, Figueiredo J, Biffi R, Trentin C, Bonanni B, Feroce I, Serrano D, Cassano E, Annibale B, Melo S, Seruca R, De Lorenzi F, Ferrara F, Piagnerelli R, Roviello F, Galimberti V

E-cadherin germline mutation carriers: clinical management and genetic implications. Cancer metastasis reviews 33: 1081-94, 2014.  [Review] 

 doi: 10.1007/s10555-014-9528-y PMID: 25332147.

 

3. Vogelaar IP, Figueiredo J, van Rooij IA, Simões-Correia J, van der Post RS, Melo S, Seruca R, Carels CE, Ligtenberg MJ, Hoogerbrugge N

Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts. Human molecular genetics 22: 919-26, 2013.  [Article] 

 doi: 10.1093/hmg/dds497 PMID: 23197654.

 

4. Simões-Correia J, Silva DI, Melo S, Figueiredo J, Caldeira J, Pinto MT, Girão H, Pereira P, Seruca R

DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. Human molecular genetics 23: 2094-105, 2014.  [Article] 

 doi: 10.1093/hmg/ddt602 PMID: 24293545.

 

5. Corso G, Figueiredo J, La Vecchia C, Veronesi P, Pravettoni G, Macis D, Karam R, Lo Gullo R, Provenzano E, Toesca A, Mazzocco K, Carneiro F, Seruca R, Melo S, Schmitt F, Roviello F, De Scalzi AM, Intra M, Feroce I, De Camilli E, Villardita MG, Trentin C, De Lorenzi F, Bonanni B, Galimberti V

Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect. Journal of medical genetics 55: 431-441, 2018.  [Review] 

 doi: 10.1136/jmedgenet-2018-105337 PMID: 29929997.

 

6. Fernandes MS, Melo S, Velho S, Carneiro P, Carneiro F, Seruca R

Specific inhibition of p110a subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers. Oncotarget 7: 68546-68558, 2016.  [Article] 

 doi: 10.18632/oncotarget.11843 PMID: 27602501.

 

7. Brito LA, Passos-Bueno MR, Yamamoto GL, Melo S, Malcher C, Ferreira SG, Figueiredo J, Alvizi L, Kobayashi GS, Naslavsky MS, Alonso N, Felix TM, Zatz M, Seruca R

Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate. Human mutation 36: 1029-33, 2015.  [Article] 

 doi: 10.1002/humu.22827 PMID: 26123647.

 

8. Sanches JM, Figueiredo J, Fonseca M, Durães C, Melo S, Esménio S, Seruca R

Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants. European journal of human genetics : EJHG 23: 1072-9, 2015.  [Article] 

 doi: 10.1038/ejhg.2014.240 PMID: 25388006.

 

9. Figueiredo J, Rodrigues I, Ribeiro J, Fernandes MS, Melo S, Sousa B, Paredes J, Seruca R, Sanches JM

Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept. Scientific reports 8: 10266, 2018.  [Article] 

 doi: 10.1038/s41598-018-28570-z PMID: 29980764.

 

10. Melo S, Figueiredo J, Fernandes MS, Gonçalves M, Morais-de-Sá E, Sanches JM, Seruca R

Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer. International journal of molecular sciences 18: ., 2017.  [Review] 

 doi: 10.3390/ijms18122687 PMID: 29231860.

 

11. Zhang L, Xiao A, Ruggeri J, Bacares R, Somar J, Melo S, Figueiredo J, Simões-Correia J, Seruca R, Shah M

The germline CDH1 c.48 G>C substitution contributes to cancer predisposition through generation of a pro-invasive mutation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis  1, 2014.  [Article] 

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12. Pena-Couso L, Perea J, Melo S, Mercadillo F, Figueiredo J, Sanches JM, Sánchez-Ruiz A, Robles L, Seruca R, Urioste M

Clinical and functional characterization of the CDH1 germline variant c.1679C>G in three unrelated families with hereditary diffuse gastric cancer. European journal of human genetics : EJHG 26: 1348-1353, 2018.  [Article] 

 doi: 10.1038/s41431-018-0173-8 PMID: 29769627.

 

13. Carneiro P, Fernandes MS, Figueiredo J, Caldeira J, Carvalho J, Pinheiro H, Leite M, Melo S, Oliveira P, Simões-Correia J, Oliveira MJ, Carneiro F, Figueiredo C, Paredes J, Oliveira C, Seruca R

E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions. FEBS letters 586: 2981-9, 2012.  [Review] 

 doi: 10.1016/j.febslet.2012.07.045 PMID: 22841718.