1. Kaurah P, MacMillan A, Boyd N, Senz J, De Luca A, Chun N, Suriano G, Zaor S, Van Manen L, Gilpin C, Nikkel S, Connolly-Wilson M, Weissman S, Rubinstein WS, Sebold C, Greenstein R, Stroop J, Yim D, Panzini B, McKinnon W, Greenblatt M, Wirtzfeld D, Fontaine D, Coit D, Yoon S, Chung D, Lauwers G, Pizzuti A, Vaccaro C, Redal MA, Oliveira C, Tischkowitz M, Olschwang S, Gallinger S, Lynch H, Green J, Ford J, Pharoah P, Fernandez B, Huntsman D

Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA : the journal of the American Medical Association 297: 2360-72, 2007.  [Article] 

 doi: 10.1001/jama.297.21.2360 PMID: 17545690.

 

2. Azevedo L, Suriano G, van Asch B, Harding RM, Amorim A

Epistatic interactions: how strong in disease and evolution? Trends in genetics : TIG 22: 581-5, 2006.  [Article] 

 doi: 10.1016/j.tig.2006.08.001 PMID: 16911842.

 

3. Canedo P, Corso G, Pereira F, Lunet N, Suriano G, Figueiredo C, Pedrazzani C, Moreira H, Barros H, Carneiro F, Seruca R, Roviello F, Machado JC

The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma. Gut 57: 1504-8, 2008.  [Article] 

 doi: 10.1136/gut.2007.143578 PMID: 18593809.

 

4. Bajpai S, Correia J, Feng Y, Figueiredo J, Sun SX, Longmore GD, Suriano G, Wirtz D

{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proceedings of the National Academy of Sciences of the United States of America 105: 18331-6, 2008.  [Article] 

 doi: 10.1073/pnas.0806783105 PMID: 19017792.

 

5. Suriano G, Oliveira C, Ferreira P, Machado JC, Bordin MC, De Wever O, Bruyneel EA, Moguilevsky N, Grehan N, Porter TR, Richards FM, Hruban RH, Roviello F, Huntsman D, Mareel M, Carneiro F, Caldas C, Seruca R

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Human molecular genetics 12: 575-82, 2003.  [Article] 

 PMID: 12588804.

 

6. Suriano G, Oliveira MJ, Huntsman D, Mateus AR, Ferreira P, Casares F, Oliveira C, Carneiro F, Machado JC, Mareel M, Seruca R

E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells. Human molecular genetics 12: 3007-16, 2003.  [Article] 

 doi: 10.1093/hmg/ddg316 PMID: 14500541.

 

7. Pereira PS, Teixeira A, Pinho S, Ferreira P, Fernandes J, Oliveira C, Seruca R, Suriano G, Casares F

E-cadherin missense mutations, associated with hereditary diffuse gastric cancer (HDGC) syndrome, display distinct invasive behaviors and genetic interactions with the Wnt and Notch pathways in Drosophila epithelia. Human molecular genetics 15: 1704-12, 2006.  [Article] 

 doi: 10.1093/hmg/ddl093 PMID: 16600987.

 

8. Velho S, Oliveira C, Paredes J, Sousa S, Leite M, Matos P, Milanezi F, Ribeiro AS, Mendes N, Licastro D, Karhu A, Oliveira MJ, Ligtenberg M, Hamelin R, Carneiro F, Lindblom A, Peltomaki P, Castedo S, Schwartz S, Jordan P, Aaltonen LA, Hofstra RM, Suriano G, Stupka E, Fialho AM, Seruca R

Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours. Human molecular genetics 19: 697-706, 2010.  [Article] 

 doi: 10.1093/hmg/ddp536 PMID: 19955118.

 

9. Mateus AR, Seruca R, Machado JC, Keller G, Oliveira MJ, Suriano G, Luber B

EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells. Human molecular genetics 16: 1639-47, 2007.  [Article] 

 doi: 10.1093/hmg/ddm113 PMID: 17510211.

 

10. Suriano G, Azevedo L, Novais M, Boscolo B, Seruca R, Amorim A, Ghibaudi EM

In vitro demonstration of intra-locus compensation using the ornithine transcarbamylase protein as model. Human molecular genetics 16: 2209-14, 2007.  [Article] 

 doi: 10.1093/hmg/ddm172 PMID: 17613537.

 

11. Ferreira AC, Suriano G, Mendes N, Gomes B, Wen X, Carneiro F, Seruca R, Machado JC

E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2. Human molecular genetics 21: 334-43, 2012.  [Article] 

 doi: 10.1093/hmg/ddr469 PMID: 21989054.

 

12. Simões-Correia J, Figueiredo J, Oliveira C, van Hengel J, Seruca R, van Roy F, Suriano G

Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer. Human molecular genetics 17: 3566-76, 2008.  [Article] 

 doi: 10.1093/hmg/ddn249 PMID: 18772194.

 

13. Oliveira C, Bordin MC, Grehan N, Huntsman D, Suriano G, Machado JC, Kiviluoto T, Aaltonen L, Jackson CE, Seruca R, Caldas C

Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. Human mutation 19: 510-7, 2002.  [Article] 

 doi: 10.1002/humu.10068 PMID: 11968083.

 

14. Suriano G, Mulholland D, de Wever O, Ferreira P, Mateus AR, Bruyneel E, Nelson CC, Mareel MM, Yokota J, Huntsman D, Seruca R

The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion. Oncogene 22: 5716-9, 2003.  [Article] 

 doi: 10.1038/sj.onc.1206672 PMID: 12944922.

 

15. Seixas S, Suriano G, Carvalho F, Seruca R, Rocha J, Di Rienzo A

Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2. Molecular biology and evolution 24: 587-98, 2007.  [Article] 

 doi: 10.1093/molbev/msl187 PMID: 17135331.

 

16. More H, Humar B, Weber W, Ward R, Christian A, Lintott C, Graziano F, Ruzzo AM, Acosta E, Boman B, Harlan M, Ferreira P, Seruca R, Suriano G, Guilford P

Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. Human mutation 28: 203, 2007.  [Article] 

 doi: 10.1002/humu.9473 PMID: 17221870.

 

17. Costa BM, Ferreira P, Costa S, Canedo P, Oliveira P, Silva A, Pardal F, Suriano G, Machado JC, Lopes JM, Reis RM

Association between functional EGF+61 polymorphism and glioma risk. Clinical cancer research : an official journal of the American Association for Cancer Research 13: 2621-6, 2007.  [Article] 

 doi: 10.1158/1078-0432.CCR-06-2606 PMID: 17473192.

 

18. Oliveira MJ, Costa AC, Costa AM, Henriques L, Suriano G, Atherton JC, Machado JC, Carneiro F, Seruca R, Mareel M, Leroy A, Figueiredo C

Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner. The Journal of biological chemistry 281: 34888-96, 2006.  [Article] 

 doi: 10.1074/jbc.M607067200 PMID: 16990273.

 

19. Regalo G, Canedo P, Suriano G, Resende C, Campos ML, Oliveira MJ, Figueiredo C, Rodrigues-Pereira P, Blin N, Seruca R, Carneiro F, Machado JC

C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression. The Journal of pathology 210: 398-404, 2006.  [Article] 

 doi: 10.1002/path.2063 PMID: 16981245.

 

20. Suriano G, Yew S, Ferreira P, Senz J, Kaurah P, Ford JM, Longacre TA, Norton JA, Chun N, Young S, Oliveira MJ, Macgillivray B, Rao A, Sears D, Jackson CE, Boyd J, Yee C, Deters C, Pai GS, Hammond LS, McGivern BJ, Medgyesy D, Sartz D, Arun B, Oelschlager BK, Upton MP, Neufeld-Kaiser W, Silva OE, Donenberg TR, Kooby DA, Sharma S, Jonsson BA, Gronberg H, Gallinger S, Seruca R, Lynch H, Huntsman DG

Characterization of a recurrent germ line mutation of the E-cadherin gene: implications for genetic testing and clinical management. Clinical cancer research : an official journal of the American Association for Cancer Research 11: 5401-9, 2005.  [Article] 

 doi: 10.1158/1078-0432.CCR-05-0247 PMID: 16061854.

 

21. Alazzouzi H, Suriano G, Guerra A, Plaja A, Espín E, Armengol M, Alhopuro P, Velho S, Shinomura Y, González-Aguilera JJ, Yamamoto H, Aaltonen LA, Moreno V, Capellà G, Peinado MA, Seruca R, Arango D, Schwartz S

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells. Journal of medical genetics 44: 75-80, 2007.  [Article] 

 doi: 10.1136/jmg.2006.042572 PMID: 16825434.

 

22. Suriano G, Seixas S, Rocha J, Seruca R

A model to infer the pathogenic significance of CDH1 germline missense variants. Journal of molecular medicine (Berlin, Germany) 84: 1023-31, 2006.  [Article] 

 doi: 10.1007/s00109-006-0091-z PMID: 16924464.

 

23. da Cunha CB, Oliveira C, Wen X, Gomes B, Sousa S, Suriano G, Grellier M, Huntsman DG, Carneiro F, Granja PL, Seruca R

De novo expression of CD44 variants in sporadic and hereditary gastric cancer. Laboratory investigation; a journal of technical methods and pathology 90: 1604-14, 2010.  [Article] 

 doi: 10.1038/labinvest.2010.155 PMID: 20856229.

 

24. Figueiredo J, Söderberg O, Simões-Correia J, Grannas K, Suriano G, Seruca R

The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC. European journal of human genetics : EJHG 21: 301-9, 2013.  [Article] 

 doi: 10.1038/ejhg.2012.159 PMID: 22850631.

 

25. Ferreira P, Oliveira MJ, Beraldi E, Mateus AR, Nakajima T, Gleave M, Yokota J, Carneiro F, Huntsman D, Seruca R, Suriano G

Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro. Experimental cell research 310: 99-104, 2005.  [Article] 

 doi: 10.1016/j.yexcr.2005.07.010 PMID: 16112667.

 

26. Brooks-Wilson AR, Kaurah P, Suriano G, Leach S, Senz J, Grehan N, Butterfield YS, Jeyes J, Schinas J, Bacani J, Kelsey M, Ferreira P, MacGillivray B, MacLeod P, Micek M, Ford J, Foulkes W, Australie K, Greenberg C, LaPointe M, Gilpin C, Nikkel S, Gilchrist D, Hughes R, Jackson CE, Monaghan KG, Oliveira MJ, Seruca R, Gallinger S, Caldas C, Huntsman D

Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria. Journal of medical genetics 41: 508-17, 2004.  [Article] 

 PMID: 15235021.

 

27. Keller G, Vogelsang H, Becker I, Plaschke S, Ott K, Suriano G, Mateus AR, Seruca R, Biedermann K, Huntsman D, Döring C, Holinski-Feder E, Neutzling A, Siewert JR, Höfler H

Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients. Journal of medical genetics 41: e89, 2004.  [Article] 

 PMID: 15173255.

 

28. Figueiredo J, Simões-Correia J, Söderberg O, Suriano G, Seruca R

ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones. PloS one 6: e23188, 2011.  [Article] 

 doi: 10.1371/journal.pone.0023188 PMID: 21853084.

 

29. Suriano G, Vrcelj N, Senz J, Ferreira P, Masoudi H, Cox K, Nabais S, Lopes C, Machado JC, Seruca R, Carneiro F, Huntsman DG

beta-catenin (CTNNB1) gene amplification: a new mechanism of protein overexpression in cancer. Genes, chromosomes & cancer 42: 238-46, 2005.  [Article] 

 doi: 10.1002/gcc.20135 PMID: 15609344.

 

30. Velho S, Oliveira C, Ferreira A, Ferreira AC, Suriano G, Schwartz S, Duval A, Carneiro F, Machado JC, Hamelin R, Seruca R

The prevalence of PIK3CA mutations in gastric and colon cancer. European journal of cancer (Oxford, England : 1990) 41: 1649-54, 2005.  [Article] 

 doi: 10.1016/j.ejca.2005.04.022 PMID: 15994075.

 

31. Carvalho B, Pinto M, Cirnes L, Oliveira C, Machado JC, Suriano G, Hamelin R, Carneiro F, Seruca R

Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas. European journal of cancer (Oxford, England : 1990) 39: 1222-7, 2003.  [Article] 

 PMID: 12763209.

 

32. Mateus AR, Simões-Correia J, Figueiredo J, Heindl S, Alves CC, Suriano G, Luber B, Seruca R

E-cadherin mutations and cell motility: a genotype-phenotype correlation. Experimental cell research 315: 1393-402, 2009.  [Article] 

 doi: 10.1016/j.yexcr.2009.02.020 PMID: 19268661.

 

33. Oliveira C, Ferreira P, Nabais S, Campos L, Ferreira A, Cirnes L, Alves CC, Veiga I, Fragoso M, Regateiro F, Dias LM, Moreira H, Suriano G, Machado JC, Lopes C, Castedo S, Carneiro F, Seruca R

E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients. European journal of cancer (Oxford, England : 1990) 40: 1897-903, 2004.  [Article] 

 doi: 10.1016/j.ejca.2004.04.027 PMID: 15288293.

 

34. Moutinho C, Mateus AR, Milanezi F, Carneiro F, Seruca R, Suriano G

Epidermal growth factor receptor structural alterations in gastric cancer. BMC cancer 8: 10, 2008.  [Article] 

 doi: 10.1186/1471-2407-8-10 PMID: 18199332.

 

35. Ferreira AC, Suriano G, Seruca R, Machado JC

Notch Inhibition Overturns the Apoptosis Resistance Conferred by E-cadherin Deficiency Helicobacter 14: 379-380, 2009.  [Meeting Abstract] 

.

 

36. Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Suriano G, Vindigni C, Berardi A, Garosi L, De Stefano A, Leoncini L, Seruca R, Pinto E

High incidence of familial gastric cancer in Tuscany, a region in Italy. Oncology 72: 243-7, 2007.  [Article] 

 doi: 10.1159/000113015 PMID: 18185018.

 

37. Ghibaudi E, Laurenti E, Pacchiardo C, Suriano G, Moguilevsky N, Pia Ferrari R

Organic and inorganic substrates as probes for comparing native bovine lactoperoxidase and recombinant human myeloperoxidase. Journal of inorganic biochemistry 94: 146-54, 2003.  [Article] 

 PMID: 12620685.

 

38. Carneiro F, Oliveira C, Suriano G, Seruca R

Molecular pathology of familial gastric cancer, with an emphasis on hereditary diffuse gastric cancer. Journal of clinical pathology 61: 25-30, 2008.  [Article] 

 doi: 10.1136/jcp.2006.043679 PMID: 17513507.

 

39. Caldeira J, Pereira PS, Suriano G, Casares F

Using fruitflies to help understand the molecular mechanisms of human hereditary diffuse gastric cancer. The International journal of developmental biology 53: 1557-61, 2009.  [Article] 

 doi: 10.1387/ijdb.072277jc PMID: 19247957.

 

40. Corso G, Roviello F, Paredes J, Pedrazzani C, Novais M, Correia J, Marrelli D, Cirnes L, Seruca R, Oliveira C, Suriano G

Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 33: 1061-7, 2007.  [Article] 

 doi: 10.1016/j.ejso.2007.03.001 PMID: 17434710.

 

41. Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L, Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R, Pinto E

Hereditary diffuse gastric cancer and E-cadherin: description of the first germline mutation in an Italian family. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 33: 448-51, 2007.  [Article] 

 doi: 10.1016/j.ejso.2006.10.028 PMID: 17126523.

 

42. Canedo P, Castanheira-Vale AJ, Lunet N, Pereira F, Figueiredo C, Gioia-Patricola L, Canzian F, Moreira H, Suriano G, Barros H, Carneiro F, Seruca R, Machado JC

The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 17: 28-32, 2008.  [Article] 

 doi: 10.1097/CEJ.0b013e32809b4d0f PMID: 18090907.

 

43. Lynch HT, Grady W, Suriano G, Huntsman D

Gastric cancer: new genetic developments. Journal of surgical oncology 90: 114-33; discussion 133, 2005.  [Review] 

 doi: 10.1002/jso.20214 PMID: 15895459.

 

44. Suriano G, Watanabe S, Ghibaudi EM, Bollen A, Ferrari RP, Moguilevsky N

Glu375Gln and Asp225Val mutants: about the nature of the covalent linkages between heme group and apo-Protein in bovine lactoperoxidase. Bioorganic & medicinal chemistry letters 11: 2827-31, 2001.  [Article] 

 PMID: 11597409.

 

45. Pinto M, Wu Y, Suriano G, Mensink RG, Duval A, Oliveira C, Carvalho B, Hamelin R, Seruca R, Hofstra RM

MBD4 mutations are rare in gastric carcinomas with microsatellite instability. Cancer genetics and cytogenetics 145: 103-7, 2003.  [Article] 

 PMID: 12935920.

 

46. Carneiro F, Oliveira C, Suriano G, Huntsman D, Caldas C, Seruca R

 Hereditary diffuse gastric cancer. Pathol Internat 54:  S193-S203, 2004.  [] 

.

 

47. Suriano G, Ferreira P, Mateus AR, Correia J, Henriques L, Seruca R

Genetics of hereditary diffuse gastric cancer: progress and future challenges. Future oncology (London, England) 2: 363-70, 2006.  [] 

 doi: 10.2217/14796694.2.3.363 PMID: 16787116.

 

48. Oliveira C, Suriano G, Ferreira P, Canedo P, Kaurah P, Mateus R, Ferreira A, Ferreira AC, Oliveira MJ, Figueiredo C, Carneiro F, Keller G, Huntsman D, Machado JC, Seruca R

Genetic screening for familial gastric cancer. Hereditary Cancer in Clinical Practice 2: 51-64, 2004.  [] 

 doi: 10.1186/1897-4287-2-2-51 PMID: 20233471.

 

49. Oliveira C, Suriano G, Huntsman D, Kaurah P, Machado JC, Figueiredo C, Carneiro F, Caldas C, Seruca R

Genetic screening for familial gastric cancer. Proceedings of Fifth International Gastric Cancer Congress 1: 37-44, 2003.  [] 

.