1. Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F

Familial gastric cancer: genetic susceptibility, pathology, and implications for management. The Lancet. Oncology 16: e60-e70, 2015.  [Review] 

 doi: 10.1016/S1470-2045(14)71016-2 PMID: 25638682.

 

2. Bajpai S, Correia J, Feng Y, Figueiredo J, Sun SX, Longmore GD, Suriano G, Wirtz D

{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proceedings of the National Academy of Sciences of the United States of America 105: 18331-6, 2008.  [Article] 

 doi: 10.1073/pnas.0806783105 PMID: 19017792.

 

3. Paredes J, Figueiredo J, Albergaria A, Oliveira P, Carvalho J, Ribeiro AS, Caldeira J, Costa AM, Simões-Correia J, Oliveira MJ, Pinheiro H, Pinho SS, Mateus R, Reis CA, Leite M, Fernandes MS, Schmitt F, Carneiro F, Figueiredo C, Oliveira C, Seruca R

Epithelial E- and P-cadherins: Role and clinical significance in cancer. Biochimica et Biophysica acta-Reviews on Cancer 1826: 297-311, 2012.  [Review] 

 doi: 10.1016/j.bbcan.2012.05.002 PMID: 22613680.

 

4. Figueiredo J, Melo S, Gamet K, Godwin T, Seixas S, Sanches JM, Guilford P, Seruca R

E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer. Molecular cancer 17: 112, 2018.  [Article] 

 doi: 10.1186/s12943-018-0859-0 PMID: 30068367.

 

5. Carvalho S, Catarino TA, Dias AM, Kato M, Almeida A, Hessling B, Figueiredo J, Gärtner F, Sanches JM, Ruppert T, Miyoshi E, Pierce M, Carneiro F, Kolarich D, Seruca R, Yamaguchi Y, Taniguchi N, Reis CA, Pinho SS

Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer. Oncogene 35: 1619-31, 2016.  [Article] 

 doi: 10.1038/onc.2015.225 PMID: 26189796.

 

6. Pinho SS, Reis CA, Paredes J, Magalhães AM, Ferreira AC, Figueiredo J, Xiaogang W, Carneiro F, Gärtner F, Seruca R

The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin. Human molecular genetics 18: 2599-608, 2009.  [Article] 

 doi: 10.1093/hmg/ddp194 PMID: 19403558.

 

7. Ribeiro AS, Carvalho FA, Figueiredo J, Carvalho R, Mestre T, Monteiro J, Guedes AF, Fonseca M, Sanches J, Seruca R, Santos NC, Paredes J

Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells. Nanoscale 8: 19390-19401, 2016.  [Article] 

 doi: 10.1039/c6nr04465d PMID: 27847941.

 

8. Simões-Correia J, Figueiredo J, Oliveira C, van Hengel J, Seruca R, van Roy F, Suriano G

Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer. Human molecular genetics 17: 3566-76, 2008.  [Article] 

 doi: 10.1093/hmg/ddn249 PMID: 18772194.

 

9. Corso G, Figueiredo J, Biffi R, Trentin C, Bonanni B, Feroce I, Serrano D, Cassano E, Annibale B, Melo S, Seruca R, De Lorenzi F, Ferrara F, Piagnerelli R, Roviello F, Galimberti V

E-cadherin germline mutation carriers: clinical management and genetic implications. Cancer metastasis reviews 33: 1081-94, 2014.  [Review] 

 doi: 10.1007/s10555-014-9528-y PMID: 25332147.

 

10. Vogelaar IP, Figueiredo J, van Rooij IA, Simões-Correia J, van der Post RS, Melo S, Seruca R, Carels CE, Ligtenberg MJ, Hoogerbrugge N

Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts. Human molecular genetics 22: 919-26, 2013.  [Article] 

 doi: 10.1093/hmg/dds497 PMID: 23197654.

 

11. Simões-Correia J, Silva DI, Melo S, Figueiredo J, Caldeira J, Pinto MT, Girão H, Pereira P, Seruca R

DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo. Human molecular genetics 23: 2094-105, 2014.  [Article] 

 doi: 10.1093/hmg/ddt602 PMID: 24293545.

 

12. Caldeira J, Figueiredo J, Brás-Pereira C, Carneiro P, Moreira AM, Pinto MT, Relvas JB, Carneiro F, Barbosa M, Casares F, Janody F, Seruca R

E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. Human molecular genetics 24: 5891-900, 2015.  [Article] 

 doi: 10.1093/hmg/ddv312 PMID: 26246502.

 

13. Figueiredo J, Melo S, Carneiro P, Moreira AM, Fernandes MS, Ribeiro AS, Guilford P, Paredes J, Seruca R

Clinical spectrum and pleiotropic nature of CDH1 germline mutations. Journal of medical genetics 56: 199-208, 2019.  [Review] 

 doi: 10.1136/jmedgenet-2018-105807 PMID: 30661051.

 

14. Corso G, Figueiredo J, La Vecchia C, Veronesi P, Pravettoni G, Macis D, Karam R, Lo Gullo R, Provenzano E, Toesca A, Mazzocco K, Carneiro F, Seruca R, Melo S, Schmitt F, Roviello F, De Scalzi AM, Intra M, Feroce I, De Camilli E, Villardita MG, Trentin C, De Lorenzi F, Bonanni B, Galimberti V

Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect. Journal of medical genetics 55: 431-441, 2018.  [Review] 

 doi: 10.1136/jmedgenet-2018-105337 PMID: 29929997.

 

15. van der Post RS, Vogelaar IP, Carneiro F, Guilford P, Huntsman D, Hoogerbrugge N, Caldas C, Schreiber KE, Hardwick RH, Ausems MG, Bardram L, Benusiglio PR, Bisseling TM, Blair V, Bleiker E, Boussioutas A, Cats A, Coit D, DeGregorio L, Figueiredo J, Ford JM, Heijkoop E, Hermens R, Humar B, Kaurah P, Keller G, Lai J, Ligtenberg MJ, O'Donovan M, Oliveira C, Pinheiro H, Ragunath K, Rasenberg E, Richardson S, Roviello F, Schackert H, Seruca R, Taylor A, Ter Huurne A, Tischkowitz M, Joe ST, van Dijck B, van Grieken NC, van Hillegersberg R, van Sandick JW, Vehof R, van Krieken JH, Fitzgerald RC

Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. Journal of medical genetics 52: 361-374, 2015.  [Review] 

 doi: 10.1136/jmedgenet-2015-103094 PMID: 25979631.

 

16. Kluijt I, Siemerink EJ, Ausems MG, van Os TA, de Jong D, Simões-Correia J, van Krieken JH, Ligtenberg MJ, Figueiredo J, van Riel E, Sijmouns RH, Plukker JT, van Hillegersberg R, Dekker E, Oliveira C, Cats A, Hoogerbrugge N

CDH1-related hereditary diffuse gastric cancer syndrome: Clinical variations and implications for counseling.

 International journal of cancer  1, 2011.  [] 

 PMID: 22020549.

 

17. Lee K, Krempely K, Roberts ME, Anderson MJ, Carneiro F, Chao E, Dixon K, Figueiredo J, Ghosh R, Huntsman D, Kaurah P, Kesserwan C, Landrith T, Li S, Mensenkamp AR, Oliveira C, Pardo C, Pesaran T, Richardson M, Slavin TP, Spurdle AB, Trapp M, Witkowski L, Yi CS, Zhang L, Plon SE, Schrader KA, Karam R

Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline CDH1 sequence variants. Human mutation 39: 1553-1568, 2018.  [Article] 

 doi: 10.1002/humu.23650 PMID: 30311375.

 

18. Preto A, Figueiredo J, Velho S, Ribeiro AS, Soares P, Oliveira C, Seruca R

BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. The Journal of pathology 214: 320-7, 2008.  [Article] 

 doi: 10.1002/path.2295 PMID: 18098337.

 

19. Carneiro P, Moreira AM, Figueiredo J, Barros R, Oliveira P, Fernandes MS, Ferro A, Almeida R, Oliveira C, Carneiro F, Schmitt F, Paredes J, Velho S, Seruca R

S100P is a molecular determinant of E-cadherin function in gastric cancer. Cell communication and signaling : CCS 17: 155, 2019.  [Article] 

 doi: 10.1186/s12964-019-0465-9 PMID: 31767037.

 

20. Brito LA, Passos-Bueno MR, Yamamoto GL, Melo S, Malcher C, Ferreira SG, Figueiredo J, Alvizi L, Kobayashi GS, Naslavsky MS, Alonso N, Felix TM, Zatz M, Seruca R

Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate. Human mutation 36: 1029-33, 2015.  [Article] 

 doi: 10.1002/humu.22827 PMID: 26123647.

 

21. Carneiro P, Figueiredo J, Bordeira-Carriço R, Fernandes MS, Carvalho J, Oliveira C, Seruca R

Therapeutic targets associated to E-cadherin dysfunction in gastric cancer. Expert opinion on therapeutic targets 17: 1187-201, 2013.  [Review] 

 doi: 10.1517/14728222.2013.827174 PMID: 23957294.

 

22. Sanches JM, Figueiredo J, Fonseca M, Durães C, Melo S, Esménio S, Seruca R

Quantification of mutant E-cadherin using bioimaging analysis of in situ fluorescence microscopy. A new approach to CDH1 missense variants. European journal of human genetics : EJHG 23: 1072-9, 2015.  [Article] 

 doi: 10.1038/ejhg.2014.240 PMID: 25388006.

 

23. Mestre T, Figueiredo J, Ribeiro AS, Paredes J, Seruca R, Sanches JM

Quantification of topological features in cell meshes to explore E-cadherin dysfunction. Scientific reports 6: 25101, 2016.  [Article] 

 doi: 10.1038/srep25101 PMID: 27151223.

 

24. Figueiredo J, Söderberg O, Simões-Correia J, Grannas K, Suriano G, Seruca R

The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC. European journal of human genetics : EJHG 21: 301-9, 2013.  [Article] 

 doi: 10.1038/ejhg.2012.159 PMID: 22850631.

 

25. Figueiredo J, Rodrigues I, Ribeiro J, Fernandes MS, Melo S, Sousa B, Paredes J, Seruca R, Sanches JM

Geometric compensation applied to image analysis of cell populations with morphological variability: a new role for a classical concept. Scientific reports 8: 10266, 2018.  [Article] 

 doi: 10.1038/s41598-018-28570-z PMID: 29980764.

 

26. Figueiredo J, Simões-Correia J, Söderberg O, Suriano G, Seruca R

ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones. PloS one 6: e23188, 2011.  [Article] 

 doi: 10.1371/journal.pone.0023188 PMID: 21853084.

 

27. Pinho SS, Figueiredo J, Cabral J, Carvalho S, Dourado J, Magalhães A, Gärtner F, Mendonfa AM, Isaji T, Gu J, Carneiro F, Seruca R, Taniguchi N, Reis CA

E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V. Biochimica et biophysica acta 1830: 2690-700, 2013.  [Article] 

 PMID: 23671930.

 

28. Simões-Correia J, Figueiredo J, Lopes R, Stricher F, Oliveira C, Serrano L, Seruca R

E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer. PloS one 7: e33783, 2012.  [Article] 

 doi: 10.1371/journal.pone.0033783 PMID: 22470475.

 

29. Melo S, Figueiredo J, Fernandes MS, Gonçalves M, Morais-de-Sá E, Sanches JM, Seruca R

Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer. International journal of molecular sciences 18: ., 2017.  [Review] 

 doi: 10.3390/ijms18122687 PMID: 29231860.

 

30. Zhang L, Xiao A, Ruggeri J, Bacares R, Somar J, Melo S, Figueiredo J, Simões-Correia J, Seruca R, Shah M

The germline CDH1 c.48 G>C substitution contributes to cancer predisposition through generation of a pro-invasive mutation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis  1, 2014.  [Article] 

.

 

31. Pena-Couso L, Perea J, Melo S, Mercadillo F, Figueiredo J, Sanches JM, Sánchez-Ruiz A, Robles L, Seruca R, Urioste M

Clinical and functional characterization of the CDH1 germline variant c.1679C>G in three unrelated families with hereditary diffuse gastric cancer. European journal of human genetics : EJHG 26: 1348-1353, 2018.  [Article] 

 doi: 10.1038/s41431-018-0173-8 PMID: 29769627.

 

32. Mateus AR, Simões-Correia J, Figueiredo J, Heindl S, Alves CC, Suriano G, Luber B, Seruca R

E-cadherin mutations and cell motility: a genotype-phenotype correlation. Experimental cell research 315: 1393-402, 2009.  [Article] 

 doi: 10.1016/j.yexcr.2009.02.020 PMID: 19268661.

 

33. Carneiro P, Fernandes MS, Figueiredo J, Caldeira J, Carvalho J, Pinheiro H, Leite M, Melo S, Oliveira P, Simões-Correia J, Oliveira MJ, Carneiro F, Figueiredo C, Paredes J, Oliveira C, Seruca R

E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions. FEBS letters 586: 2981-9, 2012.  [Review] 

 doi: 10.1016/j.febslet.2012.07.045 PMID: 22841718.

 

34. Marques PI, Ferreira Z, Martins M, Figueiredo J, Silva DI, Castro P, Morales-Hojas R, Simões-Correia J, Seixas S

SERPINA2 Is a Novel Gene with a Divergent Function from SERPINA1. PloS one 8: e66889, 2013.  [Article] 

 doi: 10.1371/journal.pone.0066889 PMID: 23826168.

 

35. Oliveira C, Pinheiro H, Figueiredo J, Seruca R, Carneiro F

E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer. Progress in molecular biology and translational science 116: 337-59, 2013.  [Review; Book Chapter] 

 doi: 10.1016/B978-0-12-394311-8.00015-7 PMID: 23481202.

 

36. Garziera M, De Re V, Geremia S, Seruca R, Figueiredo J, Melo S, Simões-Correia J, Caggiari L, De Zorzi M, Canzonieri V, Cannizzaro R, Toffoli G

A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy. Clinical and experimental medicine 13: 149-57, 2013.  [Article] 

 doi: 10.1007/s10238-012-0184-7 PMID: 22543498.

 

37. Preto A, Gonçalves J, Rebocho AP, Figueiredo J, Meireles AM, Rocha AS, Vasconcelos HM, Seca H, Seruca R, Soares P, Sobrinho-Simões M

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations. BMC cancer 9: 387, 2009.  [Article] 

 doi: 10.1186/1471-2407-9-387 PMID: 19878585.

 

38. Zollinger AJ, Xu H, Figueiredo J, Paredes J, Seruca R, Stamenovic D, Smith ML

Dependence of Tensional Homeostasis on Cell Type and on Cell-Cell Interactions Cellular and Molecular Bioengineering 11: 175-184, 2018.  [Article] 

 doi: 10.1007/s12195-018-0527-x.

 

39. Preto A, Moutinho C, Velho S, Oliveira C, Rebocho AP, Figueiredo J, Soares P, Lopes JM, Seruca R

A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation. Virchows Archiv : an international journal of pathology 450: 619-26, 2007.  [Article] 

 doi: 10.1007/s00428-007-0420-9 PMID: 17487504.